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description Monograph verified MOC Eligible

Asenapine Use in Antipsychotic Care

Target Audience: Pharmacist, Pharmacy Tech, Physician Assistant, Physician

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local_hospital 2.00 AMA PRA Category 1™
person 2.00 AAPA Category 1
groups 2.00 IPCE Credits

Course Overview

Asenapine is a second-generation, atypical antipsychotic medication. Its labeled uses include treating adults with schizophrenia and adults and children (age 10-17) with bipolar I disorder. Asenapine comes with labeled warnings and contraindications similar to other antipsychotics. This course discusses asenapine's indications, pharmacological profile, mechanism of action, dosing, and labeled warnings and contraindications. This clinical knowledge promotes safe prescribing, improves patient monitoring, prevents adverse outcomes, and supports regulatory compliance, thereby optimizing therapeutic benefits and minimizing risks when prescribing asenapine.

Learning Objectives

Upon completion of this educational activity, participants should be able to:

  • Describe the basic pharmacological profile, use, and clinical outcomes of asenapine treatment
  • Identify the dosing and uses for asenapine
  • Compare the benefits and risks of asenapine use for patients with chronic mental illness compared to other antipsychotics
  • Identify the contraindications and potential side effects of asenapine

Faculty

Authors & Activity Planners
Becca Resnik, RN
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Becca Resnik received her nursing degree from Chattanooga State Community College. She has an MA in Translation Studies from the University of Birmingham, United Kingdom, and a BS in Nuclear Engineering Technology from Excelsior University, Albany, New York. Becca Resnik also has a Medical Writing Certificate from the University of Connecticut School of Pharmacy. Becca Resnik maintains an active Registered Nurse license.
Sandra Rogers, MD
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Sandra Rogers, MD, is a primary care physician in Texas. She is board-certified through the American Board of Family Medicine and the American Board of Internal Medicine.
Additional Faculty & Reviewers
Pamela Sardo, Pharm.D., B.S.
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Pamela Sardo, Pharm.D., B.S. is a licensed pharmacist and Freelance Medical Writer at Sardo Solutions in Texas.
L. Austin Fredrickson, MD, FACP
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Dr. Fredrickson is an assistant professor of internal medicine at Northeast Ohio Medical University, where he serves as core faculty and teaches diagnostics, therapeutics, clinical skills, and health humanities. He is board-certified in general internal medicine and practices rural primary care.

Maintenance of Certification (MOC): Continuing Certification is offered for the American Board of Internal Medicine® (ABIM) and the American Board of Pediatrics® (ABP).

Successful completion of this CME activity, which includes participation in the evaluation component, enables the participant to earn up to 2.0 Medical Knowledge MOC points. Participants will earn MOC points equivalent to the amount of CME credits claimed for the activity. It is the CME activity provider's responsibility to submit participant completion information to ACCME for the purpose of granting MOC credit.

Successful completion of this CME activity, which includes participation in the evaluation component and post-test, qualifies for MOC points with the following boards:

American Board of Internal Medicine (ABIM)
  • Geriatrics & Palliative Care
  • Hospital Medicine
  • Internal Medicine
American Board of Pediatrics (ABP)
  • Pediatrics
  • Introduction
  • Pharmacological Profile
    • Mechanism of Action
    • Contraindications
    • Doses and Formulations
    • Schizophrenia and Asenapine as a Treatment Option
    • Bipolar I Disorder and Asenapine as a Treatment Option
    • Dosing Adjustments
    • Drug-Drug Interactions
  • Adverse Effects and Warnings
    • Older Adults and Dementia
    • Temperature Regulation
    • Orthostatic Hypotension and Cardiovascular Conditions
    • Hematologic Effects
    • Central Nervous System Effects
    • Weight Gain, Hyperglycemia, and Dyslipidemia
    • Hyperprolactinemia
    • Gastrointestinal Effects
    • Neuroleptic Malignant Syndrome
    • Suicidal Behavior
    • Pregnancy and Breastfeeding
  • Asenapine's Expanding Use in Treating Hostility and Agitation
  • Asenapine Case Studies
    • Case Study 1: Bipolar I Disorder with Mania
    • Case Study 2: Bipolar I Disorder
  • Summary

From March 7, 2026 through March 7, 2029, participants must:

  1. Read the "learning objectives" and "author and planning team disclosures"
  2. Study the section entitled "educational activity"
  3. Complete the Course Test and Evaluation form. The Course Test will be graded automatically. Following successful completion of the Course Test with a score of 70% or higher, a statement of participation will be made available immediately. (No partial credit will be given.)

Credit for this course will be automatically uploaded to JA_PARS.

Faculty Planner Disclosure

The following individuals were involved in developing this activity: L. Austin Fredrickson, MD, FACP; Sandra Rogers, MD; Becca Resnik, RN; Steven Malen, PharmD, MBA; and Pamela Sardo, PharmD, BS. None of the faculty members has a conflict of interest or financial relationship related to the subject matter of this activity, except that Becca Resnik discloses that she is an independent contractor (Translator/Engineer, 08/12/2024 to present) for Johnson & Johnson, Zuchwil, Switzerland, and DePuy Synthes. Any relevant financial relationships have been mitigated.

Unlabeled Use Disclosure

The information provided in this course is general in nature, and it is designed solely to provide participants with continuing education credit(s). This course and materials are not meant to substitute for the independent, professional judgment of any participant regarding that participant's professional practice, including but not limited to patient assessment, diagnosis, treatment, and/or health management. Medical and pharmacy practices, rules, and laws vary from state to state, and this course does not cover the laws of each state; therefore, participants must consult the laws of their state as they relate to their professional practice. Healthcare professionals must consult their employer, healthcare facility, hospital, or other organization for guidelines, protocols, and procedures to follow. The information provided in this course does not replace those guidelines, protocols, and procedures, but is for academic purposes only, and this course's limited purpose is for the completion of continuing education credits. Participants are advised and acknowledge that information related to medications, their administration, dosing, contraindications, adverse reactions, interactions, warnings, precautions, or accepted uses is constantly changing. Any person taking this course understands that such a person must make an independent review of medication information before any patient assessment, diagnosis, treatment and/or health management. Any discussion of off-label use of any medication, device, or procedure is informational only, and such uses are not endorsed hereby. Nothing contained in this course represents the opinions, views, judgments, or conclusions of RxCe.com LLC. RxCe.com LLC is not liable or responsible to any person for any inaccuracy, error, or omission with respect to this course or course material.

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  • A connection to the internet

Accreditation

In support of improving patient care, RxCE.com is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.