Using Dual SGLT Inhibitors to Treat Heart Failure

Pharmacist CEU
Contact Hours: 1.0 (0.1 CEUs)

Course Summary

Heart failure, a complex and prevalent cardiovascular condition, presents challenges and opportunities for healthcare providers. Dual SGLT2 inhibitors provide a newer option for heart failure management. This course discusses the mechanisms of action, clinical evidence, and patient selection criteria applicable to the use of dual SGLT2 inhibitors. The pharmacist, supported by pharmacy staff, has a role in patient education and care coordination in heart failure management.

Course Objectives

Summarize the potential effectiveness of using dual SGLT inhibitors in heart failure management

Review the mechanism of action of sotagliflozin

Describe the warnings and precautions for the use of sotagliflozin

Recognize potential adverse events associated with the use of dual SGLT inhibitors

I. Introduction

II. Dual Sodium-Glucose Cotransporter Inhibitors

III. Prevalence and Risk Factors for Heart Failure

IV. Dual SGLT Inhibitors

V. Sotagliflozin’s Clinical Trials

VI. Sotagliflozin’s Mechanism of Action

VII. Indications for Sotagliflozin

VIII. Dosing for Sotagliflozin

IX. Sotagliflozin’s Side Effects or Adverse Events

X. Drug-Drug Interactions

XI. Handling and Storage of Sotagliflozin

XII. Sotagliflozin and Special Populations

1. Surgical Patients
2. Diabetic Ketoacidosis (DKA)
3. Volume Depletion
4. Pregnancy
5. Lactation
6. Pediatric
7. Geriatric
8. Renal Impairment
9. Hepatic Impairment

XIII. Future Trends

XIV. Patient Counseling

XV. Summary

How to Earn Credit:
To earn credit for this course, participants must:
  1. Read the course objectives and faculty planner disclosure
  2. Read the course material
  3. Complete the post-test with a minimum score of 70% and complete the course evaluation form.
  4. Results are automatically submitted to CPE Monitor

Faculty Planner Disclosure

The following individuals were involved in developing this activity: Steven Malen, PharmD, MBA, and Pamela Sardo, PharmD, BS. Pamela Sardo was an employee of Rhythm Pharmaceuticals until March 2022 and has no conflicts of interest or relationships regarding the subject matter discussed. There are no financial relationships relevant to this activity to report or disclose by any of the individuals involved in the development of this activity.

Unlabeled Use Disclosures

The information provided in this course is general in nature and it is solely designed to provide participants with continuing education credit(s). This course and materials are not meant to substitute for the independent, professional judgment of any participant regarding that participant’s professional practice, including but not limited to patient assessment, diagnosis, treatment and/or health management. Medical and pharmacy practices, rules, and laws vary from state to state, and this course does not cover the laws of each state; therefore, participants must consult the laws of their state as they relate to their professional practice. Healthcare professionals, including pharmacists and pharmacy technicians, must consult with their employer, healthcare facility, hospital, or other organization, for guidelines, protocols, and procedures they are to follow. The information provided in this course does not replace those guidelines, protocols, and procedures but is for academic purposes only, and this course’s limited purpose is for the completion of continuing education credits. Participants are advised and acknowledge that information related to medications, their administration, dosing, contraindications, adverse reactions, interactions, warnings, precautions, or accepted uses are constantly changing, and any person taking this course understands that such person must make an independent review of medication information prior to any patient assessment, diagnosis, treatment and/or health management. Any discussion of off-label use of any medication, device, or procedure is informational only and such uses are not endorsed hereby. Nothing contained in this course represents the opinions, views, judgments, or conclusions of LLC. LLC is not liable or responsible to any person for any inaccuracy, error, or omission with respect to this course, or course material.

Computer Hardware/Software Requirements

Please ensure the device you plan to use meets these requirements and specifications:

  • Operating System: Windows 7,8,10, or 11 /Mac OS X 10.9 or later/iOS/Android
  • Supported Browsers: Microsoft Edge, Firefox, Google Chrome, Safari, Opera
  • A connection to the internet
  • For Live Webinars or Conferences: GoToWebinar application for iOS, Android, Mac, or PC. You cannot 'call into' a live conference.

  • Target Audience: Pharmacist
  • Contact Hours: 1.0 (0.1 CEUs)
  • Activity Release Date: 10/27/2023
  • Activity Expiration Date: 10/27/2026
  • Activity Type: Knowledge
  • UAN: 0669-0000-23-180-H01-P
  • Topic: Disease State Management/Drug Therapy
  • CeBroker Number: 20-1120874


Steve Malen, PharmD, MBA



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