Treating Recalcitrant Acne: Isotretinoin as an Option
Monograph
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Course Summary
Since 1982, isotretinoin has been known as an effective treatment for acne; however, from isotretinoin’s introduction, there was evidence that it could cause birth defects in fetuses exposed to the drug during gestation, especially during the first trimester. This course discusses the basic pharmacological profile, use, and clinical outcomes of isotretinoin treatment, its contraindications and side effects, and risk mitigation of potential birth defects in women who take isotretinoin while pregnant.
Course Objectives
Identify the use of isotretinoin for acne
Describe the basic pharmacological profile, use, and clinical outcomes of isotretinoin treatment
Describe the potential contraindications and side effects
Discuss risk mitigation of isotretinoin through IPLEDGE and pharmacy counseling
I. Introduction
II. History of Isotretinoin
III. Isotretinoin’s Teratogenic Effects
IV. Clinical Pharmacology
1. Mechanism of Action
2. Pharmacokinetics
3. Labeled and Off-label Uses
V. Dosage and Administration
1. Maximum Dosage
2. Administration
VI. Contraindications
VII. Warnings
VIII. Adverse Reactions
IX. Drug Interactions
X. Guidelines for Isotretinoin Therapy
XI. Lookalike or Soundalike Concerns
XII. Storage and Handling
XIII. Patient Counseling
XIV. Clinical Pearls
XV. Summary
- Read the course objectives and faculty planner disclosure
- Read the course material
- Complete the post-test with a minimum score of 70% and complete the course evaluation form.
- Results are automatically submitted to CPE Monitor
Faculty Planner Disclosure
The following individuals were involved in developing this activity: Steven Malen, PharmD, MBA, and Pamela Sardo, PharmD, BS. Pamela Sardo, Pharm.D., B.S., was an employee of Rhythm Pharmaceuticals until March 2022 and has no conflicts of interest or relationships regarding the subject matter discussed. There are no financial relationships relevant to this activity to report or disclose by any of the individuals involved in the development of this activity.
Unlabeled Use Disclosures
The information provided in this course is general in nature and it is solely designed to provide participants with continuing education credit(s). This course and materials are not meant to substitute for the independent, professional judgment of any participant regarding that participant’s professional practice, including but not limited to patient assessment, diagnosis, treatment and/or health management. Medical and pharmacy practices, rules, and laws vary from state to state, and this course does not cover the laws of each state; therefore, participants must consult the laws of their state as they relate to their professional practice. Healthcare professionals, including pharmacists and pharmacy technicians, must consult with their employer, healthcare facility, hospital, or other organization, for guidelines, protocols, and procedures they are to follow. The information provided in this course does not replace those guidelines, protocols, and procedures but is for academic purposes only, and this course’s limited purpose is for the completion of continuing education credits. Participants are advised and acknowledge that information related to medications, their administration, dosing, contraindications, adverse reactions, interactions, warnings, precautions, or accepted uses are constantly changing, and any person taking this course understands that such person must make an independent review of medication information prior to any patient assessment, diagnosis, treatment and/or health management. Any discussion of off-label use of any medication, device, or procedure is informational only and such uses are not endorsed hereby. Nothing contained in this course represents the opinions, views, judgments, or conclusions of RxCe.com LLC. RxCe.com LLC is not liable or responsible to any person for any inaccuracy, error, or omission with respect to this course, or course material.
Computer Hardware/Software Requirements
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- Target Audience: Pharmacy Tech
- Contact Hours: 1.0 (0.1 CEUs)
- Activity Release Date: 7/18/2023
- Activity Expiration Date: 7/18/2026
- Activity Type: Knowledge
- UAN: 0669-0000-23-105-H01-T
- Topic: Disease State Management/Drug Therapy
- CeBroker Number: 20-1089708
Author:
RxCe.com, LLC is accredited by the Accreditation Council for Pharmacy Education as a provider of continuing pharmacy education.
RxCe.com, LLC, offers pharmacy technician continuing education courses for PTCB recertification. Pharmacy technician courses are indicated both in the Target Audience description and the ACPE UAN which will end with a "T".