Psychotropics and Hyperprolactinemia

Pharmacist CEU
Contact Hours: 1.0 (0.1 CEUs)

Course Summary

Hyperprolactinemia is a well-known occurrence in people who are treated with psychotropic medications, notably antipsychotic medication for the treatment of schizophrenia and bipolar disorder. When reviewing the clinical effects of hyperprolactinemia with patients, pharmacists and prescribers should discuss common clinical consequences and possible options for therapy. People who are treated for a serious mental illness are at higher risk of developing hyperprolactinemia than healthy people within the general population. These patients require routine serum prolactin testing and physical assessment to determine whether complications from the treatment have occurred. Hyperprolactinemia may cause clinically significant concerns that require consideration of treatment benefits and risks for a patient.

Course Objectives

Describe the methods of controlling elevated prolactin levels used to reduce the risk of hyperprolactinemia

Identify the well-known side effects of psychotropic medication, specifically from the use of antipsychotics in people with schizophrenia and bipolar disorder

Compare the risks and corresponding complications of hyperprolactinemia in males and females

Identify treatments that may lower serum prolactin levels

I. Introduction

II. Prolactin: Secretion and Function

1. Estrogen and Progesterone
2. Other Factors Regulating Prolactin Secretion
3. Function of Prolactin

III. Antipsychotic-induced Hyperprolactinemia

IV. Case Study: Hyperprolactinemia and Bromocriptine

V. Case Study: Aripiprazole and Levels of Hyperprolactinemia

VI. Summary

How to Earn Credit:
To earn credit for this course, participants must:
  1. Read the course objectives and faculty planner disclosure
  2. Read the course material
  3. Complete the post-test with a minimum score of 70% and complete the course evaluation form.
  4. Results are automatically submitted to CPE Monitor

Faculty Planner Disclosure

The following individuals were involved in the development of this activity: Steve Malen, PharmD, and Susan DePasquale, MSN, PMHNP-BC. There are no financial relationships relevant to this activity to report or disclose by any of the individuals involved in the development of this activity.

Unlabeled Use Disclosures

The information provided in this course is general in nature and it is solely designed to provide participants with continuing education credit(s). This course and materials are not meant to substitute for the independent, professional judgment of any participant regarding that participant’s professional practice, including but not limited to patient assessment, diagnosis, treatment and/or health management. Medical and pharmacy practices, rules, and laws vary from state to state, and this course does not cover the laws of each state; therefore, participants must consult the laws of their state as they relate to their professional practice. Healthcare professionals, including pharmacists and pharmacy technicians, must consult with their employer, healthcare facility, hospital, or other organization, for guidelines, protocols, and procedures they are to follow. The information provided in this course does not replace those guidelines, protocols, and procedures but is for academic purposes only, and this course’s limited purpose is for the completion of continuing education credits. Participants are advised and acknowledge that information related to medications, their administration, dosing, contraindications, adverse reactions, interactions, warnings, precautions, or accepted uses are constantly changing, and any person taking this course understands that such person must make an independent review of medication information prior to any patient assessment, diagnosis, treatment and/or health management. Any discussion of off-label use of any medication, device, or procedure is informational only and such uses are not endorsed hereby. Nothing contained in this course represents the opinions, views, judgments, or conclusions of LLC. LLC is not liable or responsible to any person for any inaccuracy, error, or omission with respect to this course, or course material.

Computer Hardware/Software Requirements

Please ensure the device you plan to use meets these requirements and specifications:

  • Operating System: Windows 7,8,10, or 11 /Mac OS X 10.9 or later/iOS/Android
  • Supported Browsers: Microsoft Edge, Firefox, Google Chrome, Safari, Opera
  • A connection to the internet
  • For Live Webinars or Conferences: GoToWebinar application for iOS, Android, Mac, or PC. You cannot 'call into' a live conference.

  • Target Audience: Pharmacist
  • Contact Hours: 1.0 (0.1 CEUs)
  • Activity Release Date: 9/5/2022
  • Activity Expiration Date: 9/5/2025
  • Activity Type: Knowledge
  • UAN: 0669-0000-22-027-H01-P
  • Topic: Disease State Management/Drug Therapy
  • CeBroker Number: 20-960468


Steve Malen, PharmD, MBA



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