Oxcarbazepine and the Treatment of Partial Seizures

Pharmacist CEU
Contact Hours: 2.0 (0.2 CEUs)

Course Summary

Oxcarbazepine is an anticonvulsant (antiepileptic) that has a labeled use as a monotherapy or as an adjunctive treatment for patients who have focal seizures, also known as partial seizures. Oxcarbazepine is also used off-label to treat neuropathic pain and mania associated with bipolar disorder in adults and pediatric patients. Oxcarbazepine can cause adverse events in patients. The primary events discussed here are central nervous system events, hyponatremia, and serious dermatologic reactions. The serum sodium levels of a patient should be monitored, and multidisciplinary involvement in a treatment plan with oxcarbazepine provides the best approach for improved patient outcomes.

Course Objectives

Identify the appropriate indications for the use of oxcarbazepine

Describe the proposed mechanism of action of oxcarbazepine

List common side effects of oxcarbazepine

Discuss the increased risk of suicidal thoughts or behavior in patients who start or stop oxcarbazepine

Discuss the role of different healthcare providers in oxcarbazepine therapy

I. Introduction

II. Overview of Focal Seizures

III. History of Oxcarbazepine

IV. Clinical Pharmacology

1. Mechanism of Action
2. Pharmacokinetics
3. Labeled Uses
4. Off-label Uses
5. Available Forms
6. Dosing
7. Administration

V. Contraindications

VI. Warnings and Precautions

1. Central Nervous System (CNS)
2. Hyponatremia
3. Dermatologic Reactions
4. Hypersensitivity Reactions
5. Suicidal Behavior and Ideation
6. Withdrawal

VII. Adverse Reactions

VIII. Laboratory Tests and Monitoring

IX. Drug Interactions

X. Specific Populations

1. Pregnancy and Breastfeeding
2. Pediatric Use
3. Geriatric Use
4. Dosing Adjustment: Hepatic Impairment
5. Dosing Adjustment: Renal Impairment

XI. Misuse, Dependence, and Overdose

XII. Look-alike Sound-alike Concerns

XIII. Storage and Handling

XIV. Multidisciplinary Approach

XV. Summary

How to Earn Credit:
To earn credit for this course, participants must:
  1. Read the course objectives and faculty planner disclosure
  2. Read the course material
  3. Complete the post-test with a minimum score of 70% and complete the course evaluation form.
  4. Results are automatically submitted to CPE Monitor

Faculty Planner Disclosure

The following individuals were involved in developing this activity: Amanda Mayer, PharmD, Jeff Goldberg, PharmD, BCPP, and Pamela Sardo, PharmD, BS. Pamela Sardo, Pharm.D., B.S., was an employee of Rhythm Pharmaceuticals until March 2022 and has no conflicts of interest or relationships regarding the subject matter discussed. There are no financial relationships relevant to this activity to report or disclose by any of the individuals involved in the development of this activity.

Unlabeled Use Disclosures

The information provided in this course is general in nature and it is solely designed to provide participants with continuing education credit(s). This course and materials are not meant to substitute for the independent, professional judgment of any participant regarding that participant’s professional practice, including but not limited to patient assessment, diagnosis, treatment and/or health management. Medical and pharmacy practices, rules, and laws vary from state to state, and this course does not cover the laws of each state; therefore, participants must consult the laws of their state as they relate to their professional practice. Healthcare professionals, including pharmacists and pharmacy technicians, must consult with their employer, healthcare facility, hospital, or other organization, for guidelines, protocols, and procedures they are to follow. The information provided in this course does not replace those guidelines, protocols, and procedures but is for academic purposes only, and this course’s limited purpose is for the completion of continuing education credits. Participants are advised and acknowledge that information related to medications, their administration, dosing, contraindications, adverse reactions, interactions, warnings, precautions, or accepted uses are constantly changing, and any person taking this course understands that such person must make an independent review of medication information prior to any patient assessment, diagnosis, treatment and/or health management. Any discussion of off-label use of any medication, device, or procedure is informational only and such uses are not endorsed hereby. Nothing contained in this course represents the opinions, views, judgments, or conclusions of RxCe.com LLC. RxCe.com LLC is not liable or responsible to any person for any inaccuracy, error, or omission with respect to this course, or course material.

Computer Hardware/Software Requirements

Please ensure the device you plan to use meets these requirements and specifications:

  • Operating System: Windows 7,8,10, or 11 /Mac OS X 10.9 or later/iOS/Android
  • Supported Browsers: Microsoft Edge, Firefox, Google Chrome, Safari, Opera
  • A connection to the internet
  • For Live Webinars or Conferences: GoToWebinar application for iOS, Android, Mac, or PC. You cannot 'call into' a live conference.

  • Target Audience: Pharmacist
  • Contact Hours: 2.0 (0.2 CEUs)
  • Activity Release Date: 5/30/2023
  • Activity Expiration Date: 5/30/2026
  • Activity Type: Knowledge
  • UAN: 0669-0000-23-077-H01-P
  • Topic: Disease State Management/Drug Therapy
  • CeBroker Number: 20-1073952


Amanda Mayer, PharmD



The logo for the Accreditation Council for Pharmacy Education (ACPE).

RxCe.com, LLC is accredited by the Accreditation Council for Pharmacy Education as a provider of continuing pharmacy education.

‹‹ Back to Course List