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description Monograph

Non-Statin Therapies in Lipid Management: Practical Strategies for the Healthcare Team

Target Audience: Pharmacist

star star star star_outline star_outline 3.2/5 based on 15 ratings
schedule 2.00 Contact Hours (0.20 CEUs)
category Disease State Management/Drug Therapy
local_activity Knowledge

Course Overview

Despite the central role of statins in ASCVD risk reduction, many patients need additional or alternative therapies due to intolerance, suboptimal response, or residual risk. This continuing education activity will review the practical, evidence-based use of non-statin therapies and describe where each fits in contemporary clinical care pathways. Learners will review indications, dosing, safety and monitoring strategies, and cost and access issues. Throughout this activity, the focus will be on team-based strategies to optimize patient outcomes.

Learning Objectives

Upon completion of this educational activity, participants should be able to:

  • Describe lipid physiology and non-statin therapy targets
  • Identify indications, side effect profiles, and monitoring recommendations for lipid-lowering medications
  • Identify pharmacologic options for patients when statin therapy is intolerable, contraindicated, or subtherapeutic
  • Describe how healthcare team members can collaborate to develop patient-centered lipid management plans using non-statin therapies

Faculty

Authors & Activity Planners
Liz Fredrickson, PharmD, BCPS
View Bio +
Liz Fredrickson is an Associate Professor of Pharmacy Practice and Pharmaceutical Sciences at the Northeast Ohio Medical University College of Pharmacy. She serves as the Director of Instructional Labs and is course director for the Basic Pharmaceutics Lab and Parenteral Products and Parenteral Products Lab courses.
Pamela Sardo, Pharm.D., B.S.
View Bio +
Pamela Sardo, Pharm.D., B.S. is a licensed pharmacist and Freelance Medical Writer at Sardo Solutions in Texas.
L. Austin Fredrickson, MD, FACP
View Bio +
Dr. Fredrickson is an assistant professor of internal medicine at Northeast Ohio Medical University, where he serves as core faculty and teaches diagnostics, therapeutics, clinical skills, and health humanities. He is board-certified in general internal medicine and practices rural primary care.

I. Introduction

II. Atherosclerotic Cardiovascular Disease

III. Statins: Tolerability and Safety

IV. Lipid Physiology and Pathophysiology

V. Patient Case

VI. Non-Statin Therapies

A. Ezetimibe
B. Evolocumab and Alirocumab
C. Inclisiran
D. Omega-3 Fatty Acids
E. Bempedoic Acid
F. Evinacumab
G. Bile Acid Sequestrants
H. Niacin
I. Fibrates

VII. Return to Patient Case

VIII. Nutraceutical Alternatives

IX. Summary

From November 19, 2025 through November 19, 2028, participants must:

  1. Read the "learning objectives" and "author and planning team disclosures"
  2. Study the section entitled "educational activity"
  3. Complete the Course Test and Evaluation form. The Course Test will be graded automatically. Following successful completion of the Course Test with a score of 70% or higher, a statement of participation will be made available immediately. (No partial credit will be given.)

Credit for this course will be automatically uploaded to CPE Monitor®.

Faculty Planner Disclosure

The following individuals were involved in developing this activity: L. Austin Fredrickson, MD, FACP, Liz Fredrickson, PharmD, BCPS, and Pamela Sardo, PharmD, BS. None of the individuals involved in developing this activity has a conflict of interest or financial relationships related to the subject matter. There are no financial relationships or commercial or financial support relevant to this activity to report or disclose by RxCe.com or any of the individuals involved in the development of this activity.

Unlabeled Use Disclosure

The information provided in this course is general in nature and it is solely designed to provide participants with continuing education credit(s). This course and materials are not meant to substitute for the independent, professional judgment of any participant regarding that participant’s professional practice, including but not limited to patient assessment, diagnosis, treatment and/or health management. Medical and pharmacy practices, rules, and laws vary from state to state, and this course does not cover the laws of each state; therefore, participants must consult the laws of their state as they relate to their professional practice. Healthcare professionals, including pharmacists and pharmacy technicians, must consult with their employer, healthcare facility, hospital, or other organization, for guidelines, protocols, and procedures they are to follow. The information provided in this course does not replace those guidelines, protocols, and procedures but is for academic purposes only, and this course’s limited purpose is for the completion of continuing education credits. Participants are advised and acknowledge that information related to medications, their administration, dosing, contraindications, adverse reactions, interactions, warnings, precautions, or accepted uses are constantly changing, and any person taking this course understands that such person must make an independent review of medication information prior to any patient assessment, diagnosis, treatment and/or health management. Any discussion of off-label use of any medication, device, or procedure is informational only and such uses are not endorsed hereby. Nothing contained in this course represents the opinions, views, judgments, or conclusions of RxCe.com LLC. RxCe.com LLC is not liable or responsible to any person for any inaccuracy, error, or omission with respect to this course, or course material.

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  • Operating System: Windows 7, 8, 10, or 11 / Mac OS X 10.9 or later / iOS / Android
  • Supported Browsers: Microsoft Edge, Firefox, Google Chrome, Safari, Opera
  • A connection to the internet

Accreditation

In support of improving patient care, RxCE.com is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.