Navigating the Labyrinth of Depression: Guidelines and Strategies for Diagnosing, Managing, and Treating Depression

Pharmacist CEU
Contact Hours: 2.0 (0.2 CEUs)

Course Summary

Depression, a prevalent and disabling condition, emerges from a complex interplay of biological, environmental, and psychosocial factors. Its multifaceted nature poses challenges in its identification, treatment, and ongoing management. Unlike many other medical conditions, depression lacks definitive diagnostic tools such as imaging studies, blood tests, or pathognomonic markers. This course reviews current guidelines and evidence-based practices

Course Objectives

Define and differentiate Major Depressive Disorder according to DSM V-TR and ICD criteria

Recognize the signs and symptoms of depression

Address the role of counseling and patient education

Understand the role of screening tools in the diagnosis and management of depression

Review evidence-based pharmacologic and non-pharmacologic treatment strategies for depression

I. Introduction

II. The Clinical Presentation of Depression

III. Historical Overview

IV. Epidemiology

V. Diagnosing Depression

VI. Differential Diagnosis and Comorbidity

1. Comorbid Disorders of Mental Health
2. Medical Conditions and Medications
3. Evaluating Suicidal Risk

VII. Treating Depression

1. Psychotherapy
2. Medications for Treating Depression

VIII. Clinical Pearls Regarding Antidepressants

1. Boxed Warning
2. Stopping an Antidepressant
3. Serotonin Syndrome
4. Cytochrome P450 (CYP450)
5. Adjunct Interventions in the Treatment of Depression
6. Older Adults and Medical Comorbidities

IX. Case Example Conclusion

X. Summary

How to Earn Credit:
To earn credit for this course, participants must:
  1. Read the course objectives and faculty planner disclosure
  2. Read the course material
  3. Complete the post-test with a minimum score of 70% and complete the course evaluation form.
  4. Results are automatically submitted to CPE Monitor

Faculty Planner Disclosure

The following individuals were involved in developing this activity: Ellen Feldman, MD, and Pamela Sardo, PharmD, BS. Pamela Sardo was an employee of Rhythm Pharmaceuticals until March 2022 and has no conflicts of interest or relationships regarding the subject matter discussed. There are no financial relationships relevant to this activity to report or disclose by any of the individuals involved in the development of this activity.

Unlabeled Use Disclosures

The information provided in this course is general in nature and it is solely designed to provide participants with continuing education credit(s). This course and materials are not meant to substitute for the independent, professional judgment of any participant regarding that participant’s professional practice, including but not limited to patient assessment, diagnosis, treatment and/or health management. Medical and pharmacy practices, rules, and laws vary from state to state, and this course does not cover the laws of each state; therefore, participants must consult the laws of their state as they relate to their professional practice. Healthcare professionals, including pharmacists and pharmacy technicians, must consult with their employer, healthcare facility, hospital, or other organization, for guidelines, protocols, and procedures they are to follow. The information provided in this course does not replace those guidelines, protocols, and procedures but is for academic purposes only, and this course’s limited purpose is for the completion of continuing education credits. Participants are advised and acknowledge that information related to medications, their administration, dosing, contraindications, adverse reactions, interactions, warnings, precautions, or accepted uses are constantly changing, and any person taking this course understands that such person must make an independent review of medication information prior to any patient assessment, diagnosis, treatment and/or health management. Any discussion of off-label use of any medication, device, or procedure is informational only and such uses are not endorsed hereby. Nothing contained in this course represents the opinions, views, judgments, or conclusions of LLC. LLC is not liable or responsible to any person for any inaccuracy, error, or omission with respect to this course, or course material.

Computer Hardware/Software Requirements

Please ensure the device you plan to use meets these requirements and specifications:

  • Operating System: Windows 7,8,10, or 11 /Mac OS X 10.9 or later/iOS/Android
  • Supported Browsers: Microsoft Edge, Firefox, Google Chrome, Safari, Opera
  • A connection to the internet
  • For Live Webinars or Conferences: GoToWebinar application for iOS, Android, Mac, or PC. You cannot 'call into' a live conference.

  • Target Audience: Pharmacist
  • Contact Hours: 2.0 (0.2 CEUs)
  • Activity Release Date: 10/16/2023
  • Activity Expiration Date: 10/16/2026
  • Activity Type: Knowledge
  • UAN: 0669-0000-23-170-H01-P
  • Topic: Disease State Management/Drug Therapy
  • CeBroker Number: 20-1116896


Ellen Feldman, MD



The logo for the Accreditation Council for Pharmacy Education (ACPE)., LLC is accredited by the Accreditation Council for Pharmacy Education as a provider of continuing pharmacy education.

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