Droperidol
Monograph
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Course Summary
Droperidol is a butyrophenone class typical antipsychotic that has a labeled use in the United States for the reduction of nausea and vomiting that accompany diagnostic and surgical procedures. It is used for various off-label indications, such as to sedate acutely agitated or violent patients, to treat acute migraine, and as an adjunct for general anesthesia induction and maintenance. Pharmacists should be aware of the controversial nature of the usage restrictions of this drug, the history of the drug’s disappearance and re-emergence from use in the United States, and the risks and benefits associated with its use.
Course Objectives
Identify the indications, uses, contraindications, and potential side effects of droperidol
Describe the professional position statement guiding droperidol use in surgical and emergency cases
Compare droperidol to other treatments for acute agitation, and Describe its use in combination with other drugs
Compare medical research and case reports focused on the role of droperidol in multiple clinical settings
I. Introduction
II. Pharmacological Profile
1. Labeled and Off-label Uses
2. Administration
3. Pharmacokinetics
4. Dosage: Nausea and Vomiting
5. Dosage: Off-Label Uses
6. Dosing Adjustment
7. Lookalike/Soundalike Concerns
8. US Boxed Warning
9. Contraindications and Adverse Effects
10. Pregnancy and Breastfeeding
11. Drug-Drug Interactions
III. A Closer Look at Two Common Indications
1. Postoperative Nausea and Vomiting
2. Acute Agitation
IV. A Closer Look at Serious Adverse Drug Reactions
1. QT-Prolongation and Torsades de Pointe
2. Neuroleptic Malignant Syndrome
3. Orthostatic Hypotension
4. Extrapyramidal Symptoms
V. Summary
- Read the course objectives and faculty planner disclosure
- Read the course material
- Complete the post-test with a minimum score of 70% and complete the course evaluation form.
- Results are automatically submitted to CPE Monitor
Faculty Planner Disclosure
The following individuals were involved in the development of this activity: Kristi Monson, PharmD, BCACP, AE-C, Susan DePasquale, MSN, PMHNP-BC, Angel A. Rodriguez, PharmD. There are no financial relationships relevant to this activity to report or disclose by any of the individuals involved in the development of this activity.
Unlabeled Use Disclosures
The information provided in this course is general in nature and it is solely designed to provide participants with continuing education credit(s). This course and materials are not meant to substitute for the independent, professional judgment of any participant regarding that participant’s professional practice, including but not limited to patient assessment, diagnosis, treatment and/or health management. Medical and pharmacy practices, rules, and laws vary from state to state, and this course does not cover the laws of each state; therefore, participants must consult the laws of their state as they relate to their professional practice. Healthcare professionals, including pharmacists and pharmacy technicians, must consult with their employer, healthcare facility, hospital, or other organization, for guidelines, protocols, and procedures they are to follow. The information provided in this course does not replace those guidelines, protocols, and procedures but is for academic purposes only, and this course’s limited purpose is for the completion of continuing education credits. Participants are advised and acknowledge that information related to medications, their administration, dosing, contraindications, adverse reactions, interactions, warnings, precautions, or accepted uses are constantly changing, and any person taking this course understands that such person must make an independent review of medication information prior to any patient assessment, diagnosis, treatment and/or health management. Any discussion of off-label use of any medication, device, or procedure is informational only and such uses are not endorsed hereby. Nothing contained in this course represents the opinions, views, judgments, or conclusions of RxCe.com LLC. RxCe.com LLC is not liable or responsible to any person for any inaccuracy, error, or omission with respect to this course, or course material.
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- Target Audience: Pharmacist
- Contact Hours: 1.0 (0.1 CEUs)
- Activity Release Date: 8/29/2022
- Activity Expiration Date: 8/29/2025
- Activity Type: Knowledge
- UAN: 0669-0000-22-015-H01-P
- Topic: Disease State Management/Drug Therapy
- CeBroker Number: 20-950828
Author:
RxCe.com, LLC is accredited by the Accreditation Council for Pharmacy Education as a provider of continuing pharmacy education.