Brexpiprazole
Monograph
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Course Summary
Brexpiprazole is an atypical antipsychotic currently indicated for use as an adjunctive therapy for the treatment of major depressive disorder in adults, as well as the treatment of schizophrenia in patients ages 13 and older. This drug has also been used off-label for the treatment of severe behavioral or psychological symptoms of dementia, and agitation in patients with Alzheimer’s disease. Brexpiprazole is currently being explored as a possible treatment for unipolar and bipolar patients with treatment-resistant depression when used in combination with other drugs.
Course Objectives
Describe the basic pharmacological profile, use, and clinical outcomes of brexpiprazole treatment
Identify the uses for brexpiprazole
Compare the benefits and risks of brexpiprazole use for patients with chronic mental illness compared to other antipsychotics
Identify the contraindications and potential side effects of brexpiprazole
I. Introduction
II. History of Brexpiprazole
III. Pharmacological Profile
IV. Brexpiprazole Uses
1. Labeled Uses
2. Unlabeled Uses
V. Dosing Adjustments
VI. Contraindications, Adverse Effects, Warnings, and Precautions
1. Central Nervous System
2. Hyperglycemia and Weight Gain
3. Cardiovascular
4. Gastrointestinal
5. Dyslipidemia
6. Seizure Disorder
7. Hematologic
8. Neuroleptic Malignant Syndrome
9. Temperature Regulation
10. Geriatric Patients and Beers Criteria
11. Suicidal Ideation and Behavior
12. Pregnancy and Breastfeeding
13. Other Warnings and Precautions
VII. Brexpiprazole Overdose
VIII. Drug Interactions
IX. Studies Reviewing the Uses of Brexpiprazole
1. Major Depressive Disorder
2. Schizophrenia
3. Behavioral and Psychological Symptoms of Dementia
X. Brexpiprazole v. Aripiprazole and Cariprazine
XI. Potential Future Uses for Brexpiprazole
XII. Summary
- Read the course objectives and faculty planner disclosure
- Read the course material
- Complete the post-test with a minimum score of 70% and complete the course evaluation form.
- Results are automatically submitted to CPE Monitor
Faculty Planner Disclosure
The following individuals were involved in the development of this activity: Angel A. Rodriguez, PharmD, BCACP, and Susan DePasquale, MSN. There are no financial relationships relevant to this activity to report or disclose by any of the individuals involved in the development of this activity.
Unlabeled Use Disclosures
The information provided in this course is general in nature and it is solely designed to provide participants with continuing education credit(s). This course and materials are not meant to substitute for the independent, professional judgment of any participant regarding that participant’s professional practice, including but not limited to patient assessment, diagnosis, treatment and/or health management. Medical and pharmacy practices, rules, and laws vary from state to state, and this course does not cover the laws of each state; therefore, participants must consult the laws of their state as they relate to their professional practice. Healthcare professionals, including pharmacists and pharmacy technicians, must consult with their employer, healthcare facility, hospital, or other organization, for guidelines, protocols, and procedures they are to follow. The information provided in this course does not replace those guidelines, protocols, and procedures but is for academic purposes only, and this course’s limited purpose is for the completion of continuing education credits. Participants are advised and acknowledge that information related to medications, their administration, dosing, contraindications, adverse reactions, interactions, warnings, precautions, or accepted uses are constantly changing, and any person taking this course understands that such person must make an independent review of medication information prior to any patient assessment, diagnosis, treatment and/or health management. Any discussion of off-label use of any medication, device, or procedure is informational only and such uses are not endorsed hereby. Nothing contained in this course represents the opinions, views, judgments, or conclusions of RxCe.com LLC. RxCe.com LLC is not liable or responsible to any person for any inaccuracy, error, or omission with respect to this course, or course material.
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- Target Audience: Pharmacist
- Contact Hours: 1.0 (0.1 CEUs)
- Activity Release Date: 10/18/2022
- Activity Expiration Date: 10/18/2025
- Activity Type: Knowledge
- UAN: 0669-0000-22-053-H01-P
- Topic: Disease State Management/Drug Therapy
- CeBroker Number: 20-971864
Author:
RxCe.com, LLC is accredited by the Accreditation Council for Pharmacy Education as a provider of continuing pharmacy education.