Pharmacist CEU
Contact Hours: 1.0 (0.1 CEUs)

Course Summary

Brexpiprazole is an atypical antipsychotic currently indicated for use as an adjunctive therapy for the treatment of major depressive disorder in adults, as well as the treatment of schizophrenia in patients ages 13 and older. This drug has also been used off-label for the treatment of severe behavioral or psychological symptoms of dementia, and agitation in patients with Alzheimer’s disease. Brexpiprazole is currently being explored as a possible treatment for unipolar and bipolar patients with treatment-resistant depression when used in combination with other drugs.

Course Objectives

Describe the basic pharmacological profile, use, and clinical outcomes of brexpiprazole treatment

Identify the uses for brexpiprazole

Compare the benefits and risks of brexpiprazole use for patients with chronic mental illness compared to other antipsychotics

Identify the contraindications and potential side effects of brexpiprazole

I. Introduction

II. History of Brexpiprazole

III. Pharmacological Profile

IV. Brexpiprazole Uses

1. Labeled Uses
2. Unlabeled Uses

V. Dosing Adjustments

VI. Contraindications, Adverse Effects, Warnings, and Precautions

1. Central Nervous System
2. Hyperglycemia and Weight Gain
3. Cardiovascular
4. Gastrointestinal
5. Dyslipidemia
6. Seizure Disorder
7. Hematologic
8. Neuroleptic Malignant Syndrome
9. Temperature Regulation
10. Geriatric Patients and Beers Criteria
11. Suicidal Ideation and Behavior
12. Pregnancy and Breastfeeding
13. Other Warnings and Precautions

VII. Brexpiprazole Overdose

VIII. Drug Interactions

IX. Studies Reviewing the Uses of Brexpiprazole

1. Major Depressive Disorder
2. Schizophrenia
3. Behavioral and Psychological Symptoms of Dementia

X. Brexpiprazole v. Aripiprazole and Cariprazine

XI. Potential Future Uses for Brexpiprazole

XII. Summary

How to Earn Credit:
To earn credit for this course, participants must:
  1. Read the course objectives and faculty planner disclosure
  2. Read the course material
  3. Complete the post-test with a minimum score of 70% and complete the course evaluation form.
  4. Results are automatically submitted to CPE Monitor

Faculty Planner Disclosure

The following individuals were involved in the development of this activity: Angel A. Rodriguez, PharmD, BCACP, and Susan DePasquale, MSN. There are no financial relationships relevant to this activity to report or disclose by any of the individuals involved in the development of this activity.

Unlabeled Use Disclosures

The information provided in this course is general in nature and it is solely designed to provide participants with continuing education credit(s). This course and materials are not meant to substitute for the independent, professional judgment of any participant regarding that participant’s professional practice, including but not limited to patient assessment, diagnosis, treatment and/or health management. Medical and pharmacy practices, rules, and laws vary from state to state, and this course does not cover the laws of each state; therefore, participants must consult the laws of their state as they relate to their professional practice. Healthcare professionals, including pharmacists and pharmacy technicians, must consult with their employer, healthcare facility, hospital, or other organization, for guidelines, protocols, and procedures they are to follow. The information provided in this course does not replace those guidelines, protocols, and procedures but is for academic purposes only, and this course’s limited purpose is for the completion of continuing education credits. Participants are advised and acknowledge that information related to medications, their administration, dosing, contraindications, adverse reactions, interactions, warnings, precautions, or accepted uses are constantly changing, and any person taking this course understands that such person must make an independent review of medication information prior to any patient assessment, diagnosis, treatment and/or health management. Any discussion of off-label use of any medication, device, or procedure is informational only and such uses are not endorsed hereby. Nothing contained in this course represents the opinions, views, judgments, or conclusions of LLC. LLC is not liable or responsible to any person for any inaccuracy, error, or omission with respect to this course, or course material.

Computer Hardware/Software Requirements

Please ensure the device you plan to use meets these requirements and specifications:

  • Operating System: Windows 7,8,10, or 11 /Mac OS X 10.9 or later/iOS/Android
  • Supported Browsers: Microsoft Edge, Firefox, Google Chrome, Safari, Opera
  • A connection to the internet
  • For Live Webinars or Conferences: GoToWebinar application for iOS, Android, Mac, or PC. You cannot 'call into' a live conference.

  • Target Audience: Pharmacist
  • Contact Hours: 1.0 (0.1 CEUs)
  • Activity Release Date: 10/18/2022
  • Activity Expiration Date: 10/18/2025
  • Activity Type: Knowledge
  • UAN: 0669-0000-22-053-H01-P
  • Topic: Disease State Management/Drug Therapy
  • CeBroker Number: 20-971864


Angel A. Rodriguez, PharmD, BCACP



The logo for the Accreditation Council for Pharmacy Education (ACPE)., LLC is accredited by the Accreditation Council for Pharmacy Education as a provider of continuing pharmacy education.

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