Aripiprazole and Adherence to Antipsychotic Treatment Plans

Pharmacist CEU
Contact Hours: 2.0 (0.2 CEUs)

Course Summary

The percentage of patients who fail to adhere to treatment plans involving antipsychotics is extremely high. Non-adherence is primarily caused by patients stopping their antipsychotic medications because of their associated side effects. Non-adherence to treatment plans can trigger many problems for patients, including illness relapse and re-hospitalization. Many healthcare professionals have a suboptimal working knowledge of antipsychotic medication side effects, and this lack of knowledge may compromise patient care. Healthcare professionals may assist patients in mitigating common side effects to reduce non-adherence. One option is the selection of aripiprazole as the antipsychotic treatment choice. Aripiprazole can have a more favorable profile regarding side effects generally seen with antipsychotics, which could lead to better patient adherence to treatment plans.

Course Objectives

Describe the basic indications of aripiprazole treatment

List the different aripiprazole dosage forms and dosing frequencies

Discuss essential psychiatric assessment specific to aripiprazole

Identify the potential side effects of antipsychotics, including aripiprazole

Outline strategies to mitigate common side effects to reduce non-adherence

I. Introduction

II. Antipsychotics and Non-adherence to Treatment Plans

III. History of Aripiprazole

IV. Clinical Pharmacology

1. Mechanism of Action
2. Pharmacokinetics

V. Labeled and Off-labeled Uses

1. Labeled Uses
2. Off-label Uses

VI. Dosage and Administration

1. Labeled Uses
2. Dosage Forms and Strengths
3. Administration

VII. Contraindications

VIII. Warnings

IX. Adverse Reactions

X. Adverse Reaction Case Report

XI. Drug Interactions

XII. Specific Populations

1. Pregnancy
2. Lactation
3. Pediatric
4. Geriatric
5. Renal Impairment
6. Hepatic Impairment

XIII. Clinical Studies

1. Bipolar I Disorder
2. Major Depressive Disorder
3. Schizophrenia
4. Autistic Disorder
5. Tourette Syndrome
6. Suicidal Ideation
7. Dementia-Related Psychosis

XIV. Look-alike/Sound-alike Concerns

XV. Storage and Handling

XVI. Patient Counseling

XVII. Case Study

XVIII. Summary

How to Earn Credit:
To earn credit for this course, participants must:
  1. Read the course objectives and faculty planner disclosure
  2. Read the course material
  3. Complete the post-test with a minimum score of 70% and complete the course evaluation form.
  4. Results are automatically submitted to CPE Monitor

Faculty Planner Disclosure

The following individuals were involved in the development of this activity: Anna S. Smith, MPH, BSN-RN, Amanda Mayer, PharmD, Yasmine S. Ali, MD, Jeff Goldberg, PharmD, BCPP, and Pamela M. Sardo, PharmD, B.S. Pamela Sardo, PharmD, BS, was an employee of Rhythm Pharmaceuticals until March 2022 and has no conflicts of interest or relationships regarding the subject matter discussed. There are no financial relationships relevant to this activity to report or disclose by any of the individuals involved in the development of this activity.

Unlabeled Use Disclosures

The information provided in this course is general in nature and it is solely designed to provide participants with continuing education credit(s). This course and materials are not meant to substitute for the independent, professional judgment of any participant regarding that participant’s professional practice, including but not limited to patient assessment, diagnosis, treatment and/or health management. Medical and pharmacy practices, rules, and laws vary from state to state, and this course does not cover the laws of each state; therefore, participants must consult the laws of their state as they relate to their professional practice. Healthcare professionals, including pharmacists and pharmacy technicians, must consult with their employer, healthcare facility, hospital, or other organization, for guidelines, protocols, and procedures they are to follow. The information provided in this course does not replace those guidelines, protocols, and procedures but is for academic purposes only, and this course’s limited purpose is for the completion of continuing education credits. Participants are advised and acknowledge that information related to medications, their administration, dosing, contraindications, adverse reactions, interactions, warnings, precautions, or accepted uses are constantly changing, and any person taking this course understands that such person must make an independent review of medication information prior to any patient assessment, diagnosis, treatment and/or health management. Any discussion of off-label use of any medication, device, or procedure is informational only and such uses are not endorsed hereby. Nothing contained in this course represents the opinions, views, judgments, or conclusions of LLC. LLC is not liable or responsible to any person for any inaccuracy, error, or omission with respect to this course, or course material.

Computer Hardware/Software Requirements

Please ensure the device you plan to use meets these requirements and specifications:

  • Operating System: Windows 7,8,10, or 11 /Mac OS X 10.9 or later/iOS/Android
  • Supported Browsers: Microsoft Edge, Firefox, Google Chrome, Safari, Opera
  • A connection to the internet
  • For Live Webinars or Conferences: GoToWebinar application for iOS, Android, Mac, or PC. You cannot 'call into' a live conference.

  • Target Audience: Pharmacist
  • Contact Hours: 2.0 (0.2 CEUs)
  • Activity Release Date: 5/26/2023
  • Activity Expiration Date: 5/26/2026
  • Activity Type: Knowledge
  • UAN: 0669-0000-23-075-H01-P
  • Topic: Disease State Management/Drug Therapy
  • CeBroker Number: 20-1066222


Anna Shurtleff Smith, MPH, BSN-RN


Amanda Mayer, PharmD



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