
- Pharmacist
- 1.5
- 2/22/2022
- 2/22/2025
- Knowledge
- 0669-0000-22-043-H08-P
- Pain Management/Opioids
- 20-955984
- Describe the pharmacology of acetaminophen
- Identify the prevalence and circumstances that give rise to acetaminophen poisoning
- Describe the criteria for diagnosing acetaminophen poisoning
- Describe treatment guidelines for acetaminophen overdose
I. Introduction
II. Acetaminophen Use and Incidence of Overdose
III. Acetaminophen Pharmacology
IV. Acetaminophen Dosing and Available Forms
1. Acetaminophen Dosing
2. Available Forms of Acetaminophen
3. Contraindications
4. Adverse Effects
5. Drug-Drug/Drug-Disease Interactions
V. Acetaminophen Toxicity
Therapeutic Dose and Potential Toxicity
VI. Clinical Presentation of Acetaminophen Poisoning
1. Phase I
2. Phase II
3. Phase III
4. Phase IV
VII. Acetaminophen Overdose and Organ Damage
1. Liver Damage
2. Renal Damage
3. Other Organ Damage
VIII. Acute Acetaminophen Overdose
1. Acetaminophen Toxic Dose and Time of Ingestion
2. Measuring Acetaminophen Serum Levels
3. Signs and Symptoms of Acetaminophen Toxicity
IX. Initial Treatment for Acetaminophen Overdose
1. Gastric Decontamination
2. Antidotal Therapy: N-Acetylcysteine
3. Modes of Administration
4. Hemodialysis
X. The Roles of Pharmacists and Pharmacy Technicians in Preventing Acetaminophen Overdose
XI. Summary