Tramadol

Tramadol is a synthetic, schedule IV opioid that is used for the treatment of acute and long-term pain, and as an analgesic agent in perioperative clinical settings. Tramadol is widely prescribed in the US and worldwide. Its historical popularity was partly due to its perceived favorable side effects profile and safety, and the perception that it was less likely to be misused than other short-acting opioids; however, tramadol may be just as misused as other opioids. Tramadol remains a popular drug to prescribe, and it does provide positive patient outcomes when it is used properly; however, it is not indicated for all patient populations, and for some patients dosing should be adjusted. Because of tramadol’s pharmacodynamics, it can cause an accidental overdose. In these cases, tramadol can cause serious morbidities and death.