Target Audience: Pharmacist, Pharmacy Technician 1.5 Credits Activity Release Date: 9/10/2021 12:00:00 AM Activity Expiration Date: 9/8/2024 12:00:00 AM Pharmacology
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Course Summary
Tramadol is a synthetic, schedule IV opioid that is used for the treatment of acute and long-term pain, and as an analgesic agent in perioperative clinical settings. Tramadol is widely prescribed in the US and worldwide. Its historical popularity was partly due to its perceived favorable side effects profile and safety, and the perception that it was less likely to be misused than other short-acting opioids; however, tramadol may be just as misused as other opioids. Tramadol remains a popular drug to prescribe and it does provide positive patient outcomes when it is used properly; however, it is not indicated for all patient populations and for some patients dosing should be adjusted. Because of tramadol’s pharmacodynamics, it can cause accidental overdose. In these cases tramadol can cause serious morbidities and death.
Course Objectives
  • Describe the basic pharmacological profile, use and clinical outcomes of tramadol treatment
  • Identify the dosing for tramadol for the treatment of acute and long-term pain
  • Compare the benefits and risks of tramadol compared to other drugs used to treat acute and long-term pain
  • Identify the contraindications and potential side effects of tramadol
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Course Syllabus

I. Introduction


II. Natural and Synthetic Opioids


III. History of Tramadol


IV. Pharmacological Profile

  1. Mechanism of Action
  2. Labelled Uses
  3. Off-label Uses
  4. Future Trends in Tramadol Use
  5. Available Forms
  6. Dosing for Tramadol
  7. Dosing Adjustments for Certain Patient Groups


V. Side Effects and Warnings for Tramadol Use

  1. US Boxed Warning
  2. Contraindications
  3. Warnings
  4. Neurologic
  5. Urologic
  6. Use During Pregnancy and Breastfeeding


VI. Tramadol Use Disorder


VII. Tramadol Overdose


VIII. Treatment of Overdose


IX. Summary

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