Target Audience: Pharmacist, Pharmacy Technician 1.5 Credits Activity Release Date: 4/19/2021 12:00:00 AM Activity Expiration Date: 4/19/2024 12:00:00 AM Pharmacology
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Course Summary
Droperidol is a butyrophenone, a typical antipsychotic and dopamine receptor antagonist that works in the chemoreceptor trigger zone. The labelled use of droperidol is for the treatment of nausea and vomiting in the surgical and diagnostic setting, although it is often used for various off-label purposes as well. After decades of successful use in the surgical and emergency department settings, droperidol fell out of favor dramatically after the FDA issued a controversial black box warning due to the risk of QT prolongation. However, after much scrutiny of the FDA decision and the available data, droperidol has re-emerged as a potentially safe and effective option, although practical utility of the drug has been limited by market shortages and periods of unavailability.
Course Objectives
  • Identify the indications, uses, contraindications and potential side effects of droperidol
  • Describe the professional position statement guiding droperidol use in surgical and emergency cases
  • Compare droperidol to other treatments for acute agitation, and Describe its use in combination with other drugs
  • Compare medical research and case reports focused on the role of droperidol in multiple clinical settings
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Course Syllabus

I. Introduction

II. Pharmacological Profile

  1. Labeled and Off-label Use
  2. Administration
  3. Pharmacokinetics
  4. Dosage: Nausea and Vomiting
  5. Dosage: Off-Label Uses
  6. Dosing Adjustment
  7. Lookalike/Soundalike Concerns
  8. US Boxed Warning
  9. Contraindications and Adverse Effects
  10. Pregnancy and Breastfeeding
  11. Drug-Drug Interactions

III. A Closer Look at Two Common Indications

  1. Postoperative Nausea and Vomiting
  2. Acute Agitation

IV. A Closer Look at Serious Adverse Drug Reactions

  1. QT-Prolongation and Torsades de Pointe
  2. Neuroleptic Malignant Syndrome
  3. Orthostatic Hypotension
  4. Extrapyramidal Symptoms

 V. Summary

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