Target Audience: Pharmacist, Pharmacy Technician 1.5 Credits Activity Release Date: 5/14/2021 12:00:00 AM Activity Expiration Date: 5/14/2024 12:00:00 AM Pharmacology
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Course Summary
Asenapine is a second-generation, atypical, antipsychotic medication that is known to be effective in the treatment of acute manic or mixed episodes for adults and children with bipolar 1 disorder, and adults with schizophrenia. It is administered as a fast-dissolving, sublingual tablet twice daily. Individuals experiencing a manic episode were typically treated with benzodiazepines and other antipsychotics but asenapine offers another option. Retrospective reviews of asenapine administration in all age groups suggest that asenapine is a useful psychotropic agent because of its ease of use as a dissolvable sublingual tablet. Pediatric patients diagnosed with severe mixed mood states who require antipsychotic treatment for symptom control may benefit from asenapine as a non-invasive agent; however, more research is needed to determine the efficacy of asenapine as compared to other psychotropic medications in this patient population. Asenapine comes with labeled warnings and contraindications similar to other antipsychotics, especially in the elderly and in patients with comorbid health conditions.
Course Objectives
  • Describe the basic pharmacological profile, use and clinical outcomes of asenapine treatment
  • Identify the dosing and uses for asenapine, as well as the recommendations when switching between antipsychotics
  • Compare the benefits and risks of asenapine use for chronic mentally illness patients compared to other antipsychotics
  • Identify the contraindications and potential side effects of asenapine
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Course Syllabus

I. Introduction

II. Pharmacological Profile and Mechanism of Action

III. Dosing Recommendations for Asenapine

  1. Bipolar I Disorder
  2. Schizophrenia
  3. Dosing Adjustments: Geriatrics, Renal and Hepatic Impairment
  4. Drug-Drug Interactions

IV. Asenapine Treatment for Psychiatric Conditions

  1. Bipolar I Disorder
  2. Manic or Mixed Episodes
  3. Schizophrenia

V. Adverse Effects, Contraindications and Warnings

  1. Elderly and Dementia
  2. Temperature Regulation
  3. Orthostatic Hypotension and Cardiovascular Conditions
  4. Hematologic
  5. Central Nervous System Weight Gain, Hyperglycemia, and Dyslipidemia
  6. Hyperprolactinemia
  7. Gastrointestinal
  8. Neuroleptic Malignant Syndrome
  9. Seizures
  10. Suicidal Behavior
  11. Pregnancy and Breastfeeding

VI. Asenapine Case Studies

  1. Case Study 1: Bipolar Disorder with Mania
  2. Case Study 2: Bipolar Disorder

VII. Summary

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